A Forced Choice Comfort Study of Olopatadine Hydrochloride 0.1% versus Ketotifen Fumarate 0.05%

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<jats:title>ABSTRACT.</jats:title><jats:p><jats:bold>Purpose:</jats:bold> To compare the ocular comfort of two ophthalmic anti‐allergic agents: olopatadine hydrochloride 0.1% and ketotifen fumarate 0.05%.</jats:p><jats:p><jats:bold>Subjects and Methods:</jats:bold> In a double‐masked, multi‐centered, randomized trial, 80 subjects were asked to make a ‘forced choice’ based on ocular comfort between one drop of olopatadine hydrochloride 0.1% instilled in one eye and one drop of ketotifen fumarate 0.05% instilled in the contralateral eye. At one site, the incidence of adverse reactions was also reported.</jats:p><jats:p><jats:bold>Results:</jats:bold> All subjects (100%) selected olopatadine as the more comfortable formulation. One site (n=35) reported a 49% incidence of moderate burning and a 49% incidence of mild burning after ketotifen instillation. One subject (2% of population) at this site experienced no ocular discomfort with ketotifen. There were no reports of discomfort associated with olopatadine instillation.</jats:p><jats:p><jats:bold>Conclusion:</jats:bold> Olopatadine is a more comfortable ophthalmic preparation than ketotifen.</jats:p>

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