Rho Proteins: Linking Signaling with Membrane Trafficking

• Anne J. Ridley

抄録

Rho proteins are well known for their effects on the actin cytoskeleton, and are activated in response to a variety of extracellular stimuli. Several Rho family members are localized to vesicular compartments, and increasing evidence suggests that they play important roles in the trafficking of vesicles on both endocytic and exocytic pathways. In particular, RhoA, RhoB, RhoD, Rac and Cdc42 have been shown to affect various steps of membrane trafficking. The underlying molecular basis for these effects of Rho proteins are incompletely understood, but in the case of Cdc42 it appears that it can drive vesicle movement through Arp2/3 complex‐mediated actin polymerization at the surface of the vesicle. This is similar to what is believed to happen when Rac and Cdc42 stimulate actin polymerization at the plasma membrane. Rho proteins may also affect membrane trafficking by altering phosphatidylinositide composition of membrane compartments, or through interactions with microtubules.

収録刊行物

• Traffic

  Traffic 2 (5), 303-310, 2001-05

  Wiley

キーワード

• Cell Biology
• Genetics
• Molecular Biology
• Biochemistry
• Structural Biology

詳細情報

• CRID: 1360011146635280384
• NII論文ID: 30013470019
• DOI: 10.1034/j.1600-0854.2001.002005303.x
• ISSN: 16000854
• ISSN: 13989219
• ISSN: http://id.crossref.org/issn/13989219
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1034%2Fj.1600-0854.2001.002005303.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1034/j.1600-0854.2001.002005303.x
• データソース種別:
  • Crossref
  • CiNii Articles