Sensitization and testing of guinea pigs with cobalt chloride

DOI Web Site Web Site 被引用文献1件

抄録

<jats:p>The guinea pig maximization, test was used to study the sensitizing potential of cobalt chloride; 1 % CoCl<jats:sub>2</jats:sub>, was used for injection and 5 % for topical application. The animals were challenged twice; in series I epicutaneous testing was performed 3 weeks after sensitization and intradermal testing after yet another week. In series II the reverse schedule was used, i, e. intradermal testing after 3 weeks and epicutaneous after 4 weeks. CoCl<jats:sub>2</jats:sub> was found to be a grade V allergen. The differences between cobalt‐exposed and control animals (which had been treated with Freund's adjuvant, petrolatum, occlusion, etc.) were statistically significant (<jats:italic>P</jats:italic> < 0.001), However, the administration of cobalt at the first challenge testing caused this difference to diminish.</jats:p>

収録刊行物

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ