Clinical effect of Diskus dry-powder inhaler at low and high inspiratory flow-rates in asthmatic children
抄録
<jats:p>In vitro studies with the Diskus inhaler at low and high flow rates show consistent doses of drug as fine particles <4.7 microm. The present study was designed to ascertain whether this in vitro flow independency translates into flow-independent clinical effect when the device is used by patients at low (30 L x min[-1]) and high (90 L x min[-1]) flow rates. A pilot study in 129 children aged 3-10 yrs demonstrated that 99% of children of 3 yrs and above can generate a flow > or = 30 L x min(-1) through the device, while 26% performed > or = 90 L x min(-1). Eighteen children aged 8-15 yrs with exercise induced asthma inhaled placebo or salmeterol 50 microg at either 30 L x min(-1) or 90 L x min(-1). Exercise challenges were carried out 1 h and 12 h after dosing. The maximum percentage fall in forced expiratory volume in one second (FEVI) after exercise 12 h after treatment was significantly less after salmeterol at either flow rates as compared to placebo. There was no significant difference in the protection from salmeterol on the day of low-flow inhalation versus the day of high-flow inhalation. Consistent in vitro fine particle dosing from the Diskus inhaler translates into a consistent clinical effect at low and high flow rates in children.</jats:p>
収録刊行物
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- European Respiratory Journal
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European Respiratory Journal 11 (2), 350-354, 1998-02-01
European Respiratory Society (ERS)
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詳細情報 詳細情報について
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- CRID
- 1363670320960128256
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- NII論文ID
- 30013491462
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- ISSN
- 13993003
- 09031936
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- データソース種別
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- Crossref
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