Immunocytochemical localization of bone morphogenetic proteins (BMPs) in salivary gland pleomorphic adenoma
抄録
<jats:p>The localization of bone morphogenetic protein (BMP)‐1, ‐2, ‐3 and transforming growth factor (TGF)‐β in normal salivary gland and pleomorphic adenoma of the salivary gland has been examined immunocytochemically. Tumor cells with BMP immunostaining in pleomorphic adenoma were associated with some solid cellular and tubuloglandular patterns, and with stellate cells in the myxoid area. In addition, in the chondroid area of three pleomorphic adenomas, chondrocyte‐like cells were positive for BMPs. It is speculated that BMPs secreted by the tumor cells play a role in the formation of the chondroid component in pleomorphic adenoma by inducing some tumor cells, probably neoplastic myoepithelial cells, to differentiate to chondrocytes by metaplastic change. No tumor cells specifically immunostained with TGF‐β were found. TGF‐β was positive in fibrous and hyalinized stroma. In the submandibular gland, only anti‐BMP‐1 antibody specifically reacted to apical portions of degenerated serous acinar cells.</jats:p>
収録刊行物
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- Journal of Oral Pathology & Medicine
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Journal of Oral Pathology & Medicine 23 (5), 232-236, 1994-05
Wiley
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詳細情報 詳細情報について
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- CRID
- 1361418521201656704
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- NII論文ID
- 30013496669
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- ISSN
- 16000714
- 09042512
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- データソース種別
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- Crossref
- CiNii Articles