<i>IRE1</i> encodes a putative protein kinase containing a membrane‐spanning domain and is required for inositol phototrophy in <i>Saccharomyces cerevisiae</i>

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<jats:title>Summary</jats:title><jats:p>A novel gene, <jats:italic>IRE1</jats:italic>, of <jats:italic>Saccharomyces cerevisiae</jats:italic> was cloned through genetic complementation of a <jats:italic>myo‐</jats:italic> inositol auxotrophic mutant. The predicted amino acid sequence indicated that <jats:italic>IRE1</jats:italic> encodes a protein of 126983 Da with two highly hydrophobic regions, probably a signal sequence and a membrane‐spanning region. The carboxy‐terminal region of <jats:italic>IRE1</jats:italic> showed close sequence similarity to the catalytic domains of protein kinases. Disruption of the <jats:italic>IRE1</jats:italic> locus caused myo‐inositol auxotrophy. The <jats:italic>IRE1</jats:italic> product is very likely a protein kinase required for myo‐inositol synthesis.</jats:p>

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