Association between mast cell chymase genotype and atopic eczema: comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory disease

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<jats:sec><jats:title>Background</jats:title><jats:p>It has remained unclear whether genetic background of patients with atopic eczema (AE) alone is identical to that of patients with both AE and atopic respiratory disease.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>We aimed to assess whether there is a genetic difference between these two groups of AE patients.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>We determined the genotype with regard to an allelic polymorphism in the gene for mast cell chymase (MCC; a serine protease secreted from mast cells) in 169 AE patients.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>MCC genotype was significantly associated with pure AE patients who did not have a predisposition to atopic respiratory disease and whose serum IgE concentration was < 500 IU/mL. The distribution of MCC genotypes also differed significantly between the latter patients and those AE patients with bronchial asthma and a serum IgE concentration of > 2000 IU/mL.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>These results suggest that pure AE is associated with genetic variants of MCC, and that the genetic basis of pure AE differs from that of AE associated with atopic asthma.</jats:p></jats:sec>

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