Repeated Metronidazole and Amoxicillin Treatment of Periodontitis. A Follow‐Up Study

• Néstor J. López

• Jorge A. Gamonal

• Benjamin Martinez

抄録

Background: The prevailing concept is that little or no clear benefit is derived from antibiotic therapy in chronic periodontitis. Studies to determine the effect of metronidazole plus amoxicillin (M+A) on adult periodontitis are questionable because standard design for clinical trials was usually not used. In addition, there is no information about the effect of M+A as the sole therapy for periodontitis. Methods: A randomized, triple‐blind, controlled clinical trial was used to determine the effect of systemic administration of M+A, as the sole therapy, in progressive adult periodontitis. Forty‐six subjects with moderate to advanced adult periodontitis who showed ≥2 mm attachment loss in at least 2 sites in the previous 2 months were entered in the study. Subjects were randomly distributed to a group who received 21 tablets of metronidazole 250 mg plus amoxicillin 500 mg, or to a group receiving a placebo (1 tablet every 8 hours for 1 week). Patients were examined every 2 months for 12 months. The M+A or placebo regimen was repeated at 4 and 8 months. No effort was made to change the oral habits of patients and they received no additional therapy. Differences between groups were assessed using the Mann‐Whitney U test. The differences at every 2‐month interval within each group were assessed using the ANOVA test. Results: Seven subjects abandoned the study; at 12 months the M+A group had 20 subjects and the placebo group 19. There were no significant differences in the clinical parameters at baseline between the 2 groups. After 2 months and thereafter, the M+A group showed significant clinical improvement while the placebo group showed a progressive deterioration of periodontal status. At 12 months compared to baseline, subjects of the M+A group showed: 1) a significant overall mean attachment gain of 0.43 mm ( P = 0.005); 2) a significant decrease of active sites ( P ≤0.03); 3) a significant increase of sites gaining attachment level ( P ≤0.01); 4) a significant reduction of pocket depth ( P ≤0.00006); and 5) a significant decrease in percentage of bleeding on probing sites (BOP) ( P ≤0.0005). Significant differences between both groups at all 2‐month evaluations were found in overall mean attachment level ( P ≤0.000004), in percent of active sites ( P ≤0.03), and in percent of BOP sites ( P ≤0.02). Sites exhibiting ≥2 mm of attachment loss in 2 successive or alternate evaluations, and periodontal abscess were noticed only in the placebo group. Conclusions: A 1‐week course of systemic M+A every 4 months, as the only therapy, arrests the progression of adult periodontitis and significantly improves the clinical parameters of the disease. J Periodontol 2000;71:79‐89.

収録刊行物

• Journal of Periodontology

  Journal of Periodontology 71 (1), 79-89, 2000-01

  Wiley

キーワード

• Periodontics
• General Engineering

詳細情報

• CRID: 1364233270844387456
• NII論文ID: 30015371585
• DOI: 10.1902/jop.2000.71.1.79
• ISSN: 19433670
• ISSN: 00223492
• Web Site: https://onlinelibrary.wiley.com/doi/full/10.1902/jop.2000.71.1.79
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  • CiNii Articles