Higher Frequency of Point Mutations in the c‐K‐<i>ras</i><i>2</i> Gene in Human Colorectal Adenomas with Severe Atypia than in Carcinomas

DOI Web Site Web Site 被引用文献3件

抄録

<jats:p>Human colorectal carcinomas may be induced from adenomas or they may occur <jats:italic>de novo.</jats:italic> To examine which is the main pathway, we analyzed point mutations at codon 12 in the c‐K‐<jats:italic>ras</jats:italic> 2 gene in 73 colorectal carcinomas, 13 metastatic tumors, 72 adenomas and 30 normal tissues. The c‐K‐<jats:italic>ras</jats:italic> 2 codon 12 mutation frequency was 0/30 in normal tissues, 0/17 in adenomas with mild atypia, 3/37 (8.1%) in adenomas with moderate atypia, 15/18 (83.3%) in adenomas with severe atypia, 19/73 (26.0%) in primary carcinomas and 3/13 (23.1%) in metastatic tumors. The mutation frequency in adenomas with severe atypia was much higher than that in carcinomas. These results indicate that many colorectal carcinomas may not be induced through adenomas with severe atypia.</jats:p>

収録刊行物

被引用文献 (3)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ