Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

DOI Web Site 被引用文献9件
  • R S Liblau
    Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA.
  • R Tisch
    Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA.
  • K Shokat
    Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA.
  • X Yang
    Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA.
  • N Dumont
    Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA.
  • C C Goodnow
    Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA.
  • H O McDevitt
    Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA.

抄録

<jats:p>The mechanism by which tolerance is induced via systemic administration of high doses of aqueous antigen has been analyzed by using mice transgenic for a T-cell receptor specific for the influenza virus hemagglutinin (HA) peptide comprising amino acids 126-138. After intravenous injection of 750 (but not 75) micrograms of HA peptide, a state of hyporesponsiveness was rapidly induced. In the thymus, in situ apoptosis in the cortex and at the corticomedullary junction was responsible for a synchronous and massive deletion of CD4+ CD8+ thymocytes. In secondary lymphoid organs, HA-reactive T cells were initially activated but were hyporesponsive at the single cell level. After 3 days, however, those cells were rapidly deleted, at least partially, through an apoptotic process. Therefore, both thymic and peripheral apoptosis, in addition to T-cell receptor desensitization, contribute to high-dose tolerance.</jats:p>

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