Mitotic factors from mammalian cells induce germinal vesicle breakdown and chromosome condensation in amphibian oocytes.

• P S Sunkara

• D A Wright

• P N Rao

抄録

Cytoplasmic extracts of HeLa cells synchronized in various phases of the cell cycle were injected into fully grown Xenopus laevis oocytes to monitor the presence of factors that can induce meiotic maturation: i.e., germinal vesicle breakdown and chromosome condensation. Extracts from GI and S phase cells had no activity. The maturation-inducing activity, which was found to be low during early and mid G2 phases, increased rapidly during late G2 and reached a peak in mitosis. The results of this study suggest that the factors that regulate the breakdown of nuclear membrane and chromosome condensation during mitosis, meiosis, and premature chromosome condensation appear to be very similar, if not identical, throughout the animal kingdom.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 76 (6), 2799-2802, 1979-06

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1361418521410915712
• NII論文ID: 30016268780
• DOI: 10.1073/pnas.76.6.2799
• ISSN: 10916490
• ISSN: 00278424
• ISSN: http://id.crossref.org/issn/00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.76.6.2799
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