Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin.

• S Dedhar

  Department of Advanced Therapeutics, British Columbia Cancer Research Centre, Vancouver, Canada.

• L Gaboury

  Department of Advanced Therapeutics, British Columbia Cancer Research Centre, Vancouver, Canada.

• P Galloway

  Department of Advanced Therapeutics, British Columbia Cancer Research Centre, Vancouver, Canada.

• C Eaves

  Department of Advanced Therapeutics, British Columbia Cancer Research Centre, Vancouver, Canada.

抄録

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a member of a family of glycoprotein hormones that stimulate the proliferation and differentiation of hemopoietic cells in vitro and in vivo. We now report that human GM-CSF can also stimulate the proliferation of two osteogenic sarcoma cell lines, a breast carcinoma cell line, a simian virus 40-transformed marrow stromal cell line, and normal marrow fibroblast precursors. These findings suggest a more general regulatory function of GM-CSF on nonhemopoietic cell types than previously anticipated. They also raise the possibility of adverse side effects of GM-CSF therapy in patients whose malignant cells may be directly stimulated by this molecule and suggest a previously unanticipated role of GM-CSF gene activation in the evolution of solid tumors and in the pathogenesis of myelofibrosis.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 85 (23), 9253-9257, 1988-12

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363670319132847488
• NII論文ID: 30016284199
• DOI: 10.1073/pnas.85.23.9253
• ISSN: 10916490
• ISSN: 00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.85.23.9253
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