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- M L Sherman
- Laboratory of Clinical Pharmacology, Dana-Farber Cancer Institute, Boston, MA.
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- R Datta
- Laboratory of Clinical Pharmacology, Dana-Farber Cancer Institute, Boston, MA.
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- D E Hallahan
- Laboratory of Clinical Pharmacology, Dana-Farber Cancer Institute, Boston, MA.
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- R R Weichselbaum
- Laboratory of Clinical Pharmacology, Dana-Farber Cancer Institute, Boston, MA.
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- D W Kufe
- Laboratory of Clinical Pharmacology, Dana-Farber Cancer Institute, Boston, MA.
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<jats:p>There is little known about the regulation of gene expression by ionizing radiation exposure. The present studies demonstrate transcriptional activation of a mammalian gene, the c-jun protooncogene, by x-rays. The c-jun gene encodes a component of the AP-1 protein complex and is important in early signaling events involved in various cellular functions. The increase in c-jun transcripts by ionizing radiation was time- and dose-dependent as determined by Northern blot analysis. Transcriptional run-on analysis demonstrated that ionizing radiation stimulates the rate of c-jun gene transcription. Furthermore, the half-life of c-jun RNA was prolonged in the absence of protein synthesis. These findings indicate that the increase in c-jun RNA observed after irradiation is regulated by transcriptional and posttranscriptional mechanisms. Moreover, the induction of c-jun by ionizing radiation was associated with an inverse dose rate effect in that decreasing the dose rate resulted in increased c-jun expression. The present results similarly demonstrate that ionizing radiation increases levels of c-fos transcripts as well as that of jun-B, another member of the jun family. Taken together, these results suggest a role for induction of early response genes in the pathophysiologic effects of ionizing radiation.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 87 (15), 5663-5666, 1990-08
Proceedings of the National Academy of Sciences
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詳細情報 詳細情報について
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- CRID
- 1363388844992042880
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- NII論文ID
- 30016287430
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- NII書誌ID
- AA10808769
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- ISSN
- 10916490
- 00278424
- http://id.crossref.org/issn/00278424
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- Crossref
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