Brain proteins in plants: an Arabidopsis homolog to neurotransmitter pathway activators is part of a DNA binding complex.
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- G Lu
- Horticultural Sciences Department, University of Florida, Gainesville.
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- A J DeLisle
- Horticultural Sciences Department, University of Florida, Gainesville.
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- N C de Vetten
- Horticultural Sciences Department, University of Florida, Gainesville.
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- R J Ferl
- Horticultural Sciences Department, University of Florida, Gainesville.
抄録
<jats:p>The G box is a well-characterized cis-acting DNA regulatory element found in the promoters of several seemingly unrelated plant genes, including the alcohol dehydrogenase (Adh) gene of Arabidopsis thaliana. Using a monoclonal antibody screening approach coupled with electrophoretic mobility shift assays, we have isolated a cDNA clone encoding a protein that is part of the in vitro protein/G box complex. The derived amino acid sequence is homologous to a class of proteins in mammalian brains described as protein kinase C inhibitors and as activators of tyrosine and tryptophan hydroxylases, the rate-limiting enzymes in the pathways leading to the catecholamines and serotonin. The fact that a homologous member of this regulatory protein family is found in plants and is associated with binding to transcriptional regulatory elements suggests a much wider role for these proteins.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 89 (23), 11490-11494, 1992-12
Proceedings of the National Academy of Sciences
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詳細情報 詳細情報について
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- CRID
- 1360014417022445184
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- NII論文ID
- 30016292742
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- ISSN
- 10916490
- 00278424
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- データソース種別
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