Manidipine regulates the transcription of cytokine genes.

• M Roth

  Department of Medicine, University of Freiburg, Federal Republic of Germany.

• R Keul

  Department of Medicine, University of Freiburg, Federal Republic of Germany.

• L R Emmons

  Department of Medicine, University of Freiburg, Federal Republic of Germany.

• W H Hörl

  Department of Medicine, University of Freiburg, Federal Republic of Germany.

• L H Block

  Department of Medicine, University of Freiburg, Federal Republic of Germany.

抄録

Manidipine, a Ca(2+)-channel blocker, at concentrations that lower elevated blood pressure, modulates the transcription rates of cytokine genes in the mesangial cells of humans that had been stimulated with platelet-derived growth factor BB isomer; although the transcription for mRNA of interleukin 1 beta and granulocyte/monocyte colony-stimulating factor was inhibited, the transcription of mRNA for interleukin 6 was enhanced. Additionally, the induction of c-fos, c-jun, and 3-hydroxy-3-methylglutaryl-coenzyme A reductase transcription was inhibited by manidipine. We conclude that manidipine, at nanomolar concentrations, is efficacious in modulating gene transcriptions that are involved in proinflammatory changes of mesangial cells. Thus, manidipine, at pharmacological concentrations that are one to two orders of magnitude lower than those required for inhibition of agonist- or depolarization (K+)-induced vasoconstriction, causes changes in the activity of the genes that code for inflammatory mediators.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 89 (9), 4071-4075, 1992-05

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363388845137843456
• NII論文ID: 30016293871
• DOI: 10.1073/pnas.89.9.4071
• ISSN: 10916490
• ISSN: 00278424
• ISSN: http://id.crossref.org/issn/00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.89.9.4071
• データソース種別:
  • Crossref
  • CiNii Articles