MACROMOLECULAR ABSORPTION

DOI PDF 被引用文献10件
  • W. A. Walker
    From the Department of Medicine, Harvard Medical School, and the Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114
  • R. Cornell
    From the Department of Medicine, Harvard Medical School, and the Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114
  • L. M. Davenport
    From the Department of Medicine, Harvard Medical School, and the Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114
  • K. J. Isselbacher
    From the Department of Medicine, Harvard Medical School, and the Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114

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<jats:p>The immature small intestine of neonatal mammals is permeable to gamma globulins as a source of passive immunity. Allegedly, macromolecular absorption ceases when the epithelial cell membrane matures. However, some evidence exists that adult animals retain a limited capacity to transport antigenic and biologically active quantities of large molecules. In this study, the mechanism of absorption of the tracer protein, horseradish peroxidase (HRP), was tested in neonatal and adult rat gut sacs. Transport into serosal fluid was quantitated by enzymatic assay and monitored morphologically by histochemical techniques. A greater transport of HRP was noted in the adult jejunum compared to adult ileum and neonatal intestine. Morphologically, the uptake mechanism in adult intestine was similar to the endocytosis previously reported in neonatal animals Like other endocytotic processes, HRP uptake in adult rats is an energy-dependent process as determined by metabolic inhibitors and temperature-controlled studies. An understanding of the mechanism whereby macromolecules are bound to intestinal membranes and engulfed by them is necessary before the action of physiologic macromolecules such as enterotoxins can be appreciated.</jats:p>

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