Pivotal Role of Dendritic Cell–derived CXCL10 in the Retention of T Helper Cell 1 Lymphocytes in Secondary Lymph Nodes

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  • Hiroyuki Yoneyama
    1Department of Molecular Preventive Medicine, School of Medicine and Core Research and Evolutional Science and Technology (CREST), The University of Tokyo, Tokyo 113-0033, Japan
  • Shosaku Narumi
    1Department of Molecular Preventive Medicine, School of Medicine and Core Research and Evolutional Science and Technology (CREST), The University of Tokyo, Tokyo 113-0033, Japan
  • Yanyun Zhang
    1Department of Molecular Preventive Medicine, School of Medicine and Core Research and Evolutional Science and Technology (CREST), The University of Tokyo, Tokyo 113-0033, Japan
  • Masako Murai
    1Department of Molecular Preventive Medicine, School of Medicine and Core Research and Evolutional Science and Technology (CREST), The University of Tokyo, Tokyo 113-0033, Japan
  • Marco Baggiolini
    3Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland
  • Antonio Lanzavecchia
    4Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland
  • Takafumi Ichida
    2Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8122, Japan
  • Hitoshi Asakura
    2Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8122, Japan
  • Kouji Matsushima
    1Department of Molecular Preventive Medicine, School of Medicine and Core Research and Evolutional Science and Technology (CREST), The University of Tokyo, Tokyo 113-0033, Japan

抄録

<jats:p>Various immune diseases are considered to be regulated by the balance of T helper (Th)1 and Th2 subsets. Although Th lymphocytes are believed to be generated in draining lymph nodes (LNs), in vivo Th cell behaviors during Th1/Th2 polarization are largely unexplored. Using a murine granulomatous liver disease model induced by Propionibacterium acnes, we show that retention of Th1 cells in the LNs is controlled by a chemokine, CXCL10/interferon (IFN) inducible protein 10 produced by mature dendritic cells (DCs). Hepatic LN DCs preferentially produced CXCL10 to attract 5′-bromo-2′-deoxyuridine (BrdU)+CD4+ T cells and form clusters with IFN-γ–producing CD4+ T cells by day 7 after antigen challenge. Blockade of CXCL10 dramatically altered the distribution of cluster-forming BrdU+CD4+ T cells. BrdU+CD4+ T cells in the hepatic LNs were selectively diminished while those in the circulation were significantly increased by treatment with anti-CXCL10 monoclonal antibody. This was accompanied by accelerated infiltration of memory T cells into the periphery of hepatic granuloma sites, most of them were in cell cycle and further produced higher amount of IFN-γ leading to exacerbation of liver injury. Thus, mature DC-derived CXCL10 is pivotal to retain Th1 lymphocytes within T cell areas of draining LNs and optimize the Th1-mediated immune responses.</jats:p>

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