Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood
-
- Helmut Jonuleit
- aDepartment of Dermatology, University of Mainz, D-55101 Mainz, Germany
-
- Edgar Schmitt
- bInstitute of Immunology, University of Mainz, D-55101 Mainz, Germany
-
- Michael Stassen
- bInstitute of Immunology, University of Mainz, D-55101 Mainz, Germany
-
- Andrea Tuettenberg
- aDepartment of Dermatology, University of Mainz, D-55101 Mainz, Germany
-
- Jurgen Knop
- aDepartment of Dermatology, University of Mainz, D-55101 Mainz, Germany
-
- Alexander H. Enk
- aDepartment of Dermatology, University of Mainz, D-55101 Mainz, Germany
抄録
<jats:p>A subpopulation of peripheral human CD4+CD25+ T cells that expresses CD45RO, histocompatibility leukocyte antigen DR, and intracellular cytotoxic T lymphocyte–associated antigen (CTLA) 4 does not expand after stimulation and markedly suppresses the expansion of conventional T cells in a contact-dependent manner. After activation, CD4+CD25+ T cells express CTLA-4 on the surface detectable for several weeks. These cells show a G1/G0 cell cycle arrest and no production of interleukin (IL)-2, IL-4, or interferon (IFN)-γ on either protein or mRNA levels. The anergic state of CD4+CD25+ T cells is not reversible by the addition of anti-CD28, anti–CTLA-4, anti–transforming growth factor β, or anti–IL-10 antibody. However, the refractory state of CD4+CD25+ T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties.</jats:p>
収録刊行物
-
- The Journal of Experimental Medicine
-
The Journal of Experimental Medicine 193 (11), 1285-1294, 2001-06-04
Rockefeller University Press
- Tweet
詳細情報
-
- CRID
- 1363951794417522432
-
- NII論文ID
- 30017415710
-
- ISSN
- 15409538
- 00221007
-
- データソース種別
-
- Crossref
- CiNii Articles