Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

  • Helmut Jonuleit
    aDepartment of Dermatology, University of Mainz, D-55101 Mainz, Germany
  • Edgar Schmitt
    bInstitute of Immunology, University of Mainz, D-55101 Mainz, Germany
  • Michael Stassen
    bInstitute of Immunology, University of Mainz, D-55101 Mainz, Germany
  • Andrea Tuettenberg
    aDepartment of Dermatology, University of Mainz, D-55101 Mainz, Germany
  • Jurgen Knop
    aDepartment of Dermatology, University of Mainz, D-55101 Mainz, Germany
  • Alexander H. Enk
    aDepartment of Dermatology, University of Mainz, D-55101 Mainz, Germany

抄録

<jats:p>A subpopulation of peripheral human CD4+CD25+ T cells that expresses CD45RO, histocompatibility leukocyte antigen DR, and intracellular cytotoxic T lymphocyte–associated antigen (CTLA) 4 does not expand after stimulation and markedly suppresses the expansion of conventional T cells in a contact-dependent manner. After activation, CD4+CD25+ T cells express CTLA-4 on the surface detectable for several weeks. These cells show a G1/G0 cell cycle arrest and no production of interleukin (IL)-2, IL-4, or interferon (IFN)-γ on either protein or mRNA levels. The anergic state of CD4+CD25+ T cells is not reversible by the addition of anti-CD28, anti–CTLA-4, anti–transforming growth factor β, or anti–IL-10 antibody. However, the refractory state of CD4+CD25+ T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties.</jats:p>

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