Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization

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  • Armelle Regnault
    From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
  • Danielle Lankar
    From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
  • Valérie Lacabanne
    From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
  • Ana Rodriguez
    From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
  • Clotilde Théry
    From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
  • Maria Rescigno
    From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
  • Takashi Saito
    From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
  • Sjef Verbeek
    From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
  • Christian Bonnerot
    From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
  • Paola Ricciardi-Castagnoli
    From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
  • Sebastian Amigorena
    From *Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France; the ‡Second University of Milan, Department of Biotechnology and Biological Sciences, 20126 Milan, Italy; the §Department of Immunology, University Hospital, G04.614, 3584 CX, Utrecht, The Netherlands; and the ‖Division of Molecular Genetics, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan

Abstract

<jats:p>Dendritic cells (DCs) express several receptors for the Fc portion of immunoglobulin (Ig)G (FcγR), which mediate internalization of antigen–IgG complexes (immune complexes, ICs) and promote efficient major histocompatibility complex (MHC) class II–restricted antigen presentation. We now show that FcγRs have two additional specific attributes in murine DCs: the induction of DC maturation and the promotion of efficient MHC class I–restricted presentation of peptides from exogenous, IgG-complexed antigens. Both FcγR functions require the FcγR-associated γ chain. FcγR-mediated MHC class I–restricted antigen presentation is extremely sensitive and specific to immature DCs. It requires proteasomal degradation and is dependent on functional peptide transporter associated with antigen processing, TAP1-TAP2. By promoting DC maturation and presentation on both MHC class I and II molecules, ICs should efficiently sensitize DCs for priming of both CD4+ helper and CD8+ cytotoxic T lymphocytes in vivo.</jats:p>

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