Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization

DOI PDF 被引用文献42件
  • Michael D. Gunn
    From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the ‡Center for Experimental Medicine and §Laboratory Animal Research Center, Institute of Medical Science, University of  Tokyo, Tokyo 108-8639, Japan; and the ‖Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan
  • Shigeru Kyuwa
    From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the ‡Center for Experimental Medicine and §Laboratory Animal Research Center, Institute of Medical Science, University of  Tokyo, Tokyo 108-8639, Japan; and the ‖Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan
  • Carmen Tam
    From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the ‡Center for Experimental Medicine and §Laboratory Animal Research Center, Institute of Medical Science, University of  Tokyo, Tokyo 108-8639, Japan; and the ‖Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan
  • Terutaka Kakiuchi
    From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the ‡Center for Experimental Medicine and §Laboratory Animal Research Center, Institute of Medical Science, University of  Tokyo, Tokyo 108-8639, Japan; and the ‖Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan
  • Akio Matsuzawa
    From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the ‡Center for Experimental Medicine and §Laboratory Animal Research Center, Institute of Medical Science, University of  Tokyo, Tokyo 108-8639, Japan; and the ‖Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan
  • Lewis T. Williams
    From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the ‡Center for Experimental Medicine and §Laboratory Animal Research Center, Institute of Medical Science, University of  Tokyo, Tokyo 108-8639, Japan; and the ‖Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan
  • Hideki Nakano
    From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the ‡Center for Experimental Medicine and §Laboratory Animal Research Center, Institute of Medical Science, University of  Tokyo, Tokyo 108-8639, Japan; and the ‖Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan

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<jats:p>Secondary lymphoid organ chemokine (SLC) is expressed in high endothelial venules and in T cell zones of spleen and lymph nodes (LNs) and strongly attracts naive T cells. In mice homozygous for the paucity of lymph node T cell (plt) mutation, naive T cells fail to home to LNs or the lymphoid regions of spleen. Here we demonstrate that expression of SLC is undetectable in plt mice. In addition to the defect in T cell homing, we demonstrate that dendritic cells (DCs) fail to accumulate in spleen and LN T cell zones of plt mice. DC migration to LNs after contact sensitization is also substantially reduced. The physiologic significance of these abnormalities in plt mice is indicated by a markedly increased sensitivity to infection with murine hepatitis virus. The plt mutation maps to the SLC locus; however, the sequence of SLC introns and exons in plt mice is normal. These findings suggest that the abnormalities in plt mice are due to a genetic defect in the expression of SLC and that SLC mediates the entry of naive T cells and antigen-stimulated DCs into the T cell zones of secondary lymphoid organs.</jats:p>

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