Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection.
抄録
<jats:p>The Ly phenotype of cells mediating skin graft rejection was determined using monoclonal anti-Lyt-1.1 and Lyt-2.1 antibodies in CBA mice that received CBA lymphoid cells from mice sensitized to C57BL/6; i.e., alloantigenic differences arising from the H-2 and non-H-2 loci. It was clear that graft rejection was due wholly to the presence of Lyt-1 cells in the inoculum and that Lyt-123 or Lyt-23 cells had no effect. Furthermore, no synergism was noted between Lyt-1 and Lyt-2 cells. In this model, both the cytotoxic T cell and cytotoxic lymphocyte precursors were shown to be Lyt-123 and these could be depleted from sensitized Lyt-1 populations that mediated graft rejection. Thus cytotoxic T cells are not responsible for skin graft rejection, but rather, this is mediated by an Lyt-1 cell. Whether this T cell is distinct from other Lyt-1 cells (T helper, T cells mediating delayed hypersensitivity) is not clear at present, but other evidence, and traditional concepts, link graft rejection and delayed type hypersensitivity as being different manifestations of the same mechanism.</jats:p>
収録刊行物
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- The Journal of experimental medicine
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The Journal of experimental medicine 153 (5), 1044-1057, 1981-05-01
Rockefeller University Press
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詳細情報
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- CRID
- 1364233269155579264
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- NII論文ID
- 30017425405
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- ISSN
- 15409538
- 00221007
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- データソース種別
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- Crossref
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