Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.
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- G J Freeman
- Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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- F Borriello
- Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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- R J Hodes
- Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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- H Reiser
- Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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- J G Gribben
- Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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- J W Ng
- Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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- J Kim
- Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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- J M Goldberg
- Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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- K Hathcock
- Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
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- G Laszlo
- Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
抄録
<jats:p>The B7-1 molecule, expressed on antigen presenting cells (APC), provides a crucial costimulatory signal for T cell activation. Recent studies demonstrate the existence of alternative, non-B7-1 CTLA4 counter-receptors in mice and humans. Here, we describe the molecular cloning and demonstrate costimulatory function of the murine B7-2 (mB7-2) gene. Murine B7-2 cDNA encodes a member of the Ig supergene family that binds CTLA4-Ig and stains with the GL1 but not anti-mB7-1 mAb. Murine B7-2 costimulates the proliferation and interleukin 2 production of CD4+ T cells and this costimulation can be inhibited by either CTLA4-Ig or GL1 mAb. Identification of the B7-2 molecule will permit further manipulation of the B7:CD28/CTLA4 costimulatory pathway which has been shown to be involved in the prevention of tolerance, induction of tumor immunity, and most recently, in the pathogenesis of autoimmunity.</jats:p>
収録刊行物
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- The Journal of experimental medicine
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The Journal of experimental medicine 178 (6), 2185-2192, 1993-12-01
Rockefeller University Press
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詳細情報 詳細情報について
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- CRID
- 1362825893745307520
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- NII論文ID
- 30017430313
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- ISSN
- 15409538
- 00221007
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- データソース種別
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