The role of B cells in lpr/lpr-induced autoimmunity.

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  • M J Shlomchik
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
  • M P Madaio
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
  • D Ni
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
  • M Trounstein
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
  • D Huszar
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.

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<jats:p>The primary roles of T cells and B cells in the initiation of systemic autoimmunity are unclear. To investigate the role of B cells, we crossed the "Jh knockout" mutation onto the autoimmune lpr/lpr background. Animals homozygous for both traits were obtained. As expected, these animals lack B cells. These animals also show no signs of autoimmune kidney destruction nor vasculitis, in spite of carrying the lpr/lpr mutation. In contrast, lpr/lpr littermates that had B cells had severe nephritis and vasculitis, as well as autoantibodies. These results demonstrate a primary role for B cells and/or (auto)antibodies in initiating several types of autoimmune-mediated tissue destruction. The implications of this finding for models and therapy of autoimmunity are discussed.</jats:p>

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