Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma

• Rossella Galli

  1Stem Cell Research Institute and

• Elena Binda

  1Stem Cell Research Institute and

• Ugo Orfanelli

  1Stem Cell Research Institute and

• Barbara Cipelletti

  1Stem Cell Research Institute and

• Angela Gritti

  1Stem Cell Research Institute and

• Simona De Vitis

  2Laboratory of Molecular Diagnostics, H. S. Raffaele, Milan, Italy;

• Roberta Fiocco

  1Stem Cell Research Institute and

• Chiara Foroni

  1Stem Cell Research Institute and

• Francesco Dimeco

  3National Neurological Institute “C. Besta,” Milan, Italy;

• Angelo Vescovi

  1Stem Cell Research Institute and

抄録

Transformed stem cells have been isolated from some human cancers. We report that, unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors endowed with all of the critical features expected from neural stem cells. Similar, yet not identical, to their normal neural stem cell counterpart, these precursors emerge as unipotent (astroglial) in vivo and multipotent (neuronal-astroglial-oligodendroglial) in culture. More importantly, these cells can act as tumor-founding cells down to the clonal level and can establish tumors that closely resemble the main histologic, cytologic, and architectural features of the human disease, even when challenged through serial transplantation. Thus, cells possessing all of the characteristics expected from tumor neural stem cells seem to be involved in the growth and recurrence of adult human glioblastomas multiforme.

収録刊行物

• Cancer Research

  Cancer Research 64 (19), 7011-7021, 2004-10-01

  American Association for Cancer Research (AACR)

キーワード

• Cancer Research
• Oncology

詳細情報

• CRID: 1363107370395631232
• NII論文ID: 30018590268
• DOI: 10.1158/0008-5472.can-04-1364
• ISSN: 15387445
• ISSN: 00085472
• ISSN: http://id.crossref.org/issn/00085472
• Web Site: https://aacrjournals.org/cancerres/article-pdf/64/19/7011/2518418/zch01904007011.pdf
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