Optical investigations of physiology. A study of intrinsic and extrinsic biomedical contrast

DOI Web Site 被引用文献6件
  • Britton Chance
    Johnson Research Foundation, Department of Biochemistry and Biophysics, University of PennsylvaniaPhiladelphia, PA 19104–6089,USA
  • Qingming Luo
    Johnson Research Foundation, Department of Biochemistry and Biophysics, University of PennsylvaniaPhiladelphia, PA 19104–6089,USA
  • Shoko Nioka
    Johnson Research Foundation, Department of Biochemistry and Biophysics, University of PennsylvaniaPhiladelphia, PA 19104–6089,USA
  • David C. Alsop
    Department of Radiologic Science, University of Pennsylvania, PhiladelpiaPA 19104–4283USA
  • John A. Detre
    Department of Neurology, University of Pennsylvania, PhiladelphiaPA 19104–4283USA
  • B. Chance
    editor
  • C. E. Cooper
    editor
  • D. T. Delpy
    editor
  • E. O. R. Reynolds
    editor

抄録

<jats:p>The utility and performance of optical studies of tissue depends upon the contrast and the changes of contrast in health and disease and in functional activity. The contrast is determined both by the optical properties of extrinsic and intrinsic chromophores and scatterers but especially upon the changes evoked by physiological activity and pathological states. Here, we have focused upon absorption changes of the intrinsic probe, blood absorbance changes due to cortical hypoxia and to haematomas, giving, for particular conditions, absorbance changes of 0.15 and over 0.4 (∠)OD, respectively. Functional activity may give changes of blood volume of over 0.05 (∠)OD with some variability due to individual responses that is best expressed as histogram displays of the distribution of response among a significant population. Responses have been observed in prefrontal parietal and occipital functions (242 tests). Extrinsic probes afford signals dependent upon the dose tolerance of the subject and can readily equal or exceed the blood volume and oxygenation signals, and currently afford vascular volume and flow indications. However, contrast agents for the functional activity of cellular function are ultimately to be expected. Finally, light–scattering changes afford osmolyte–related responses and are here shown to indicate a large signal attributed to cortical depolarization and K<jats:sup>+</jats:sup>release in hypoxia/ischaemia. Thus, the optical method affords imaging of manifold contrasts that greatly enhance its specificity and sensitivity for diagnostic procedures.</jats:p>

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