Lsh, a member of the SNF2 family, is required for genome-wide methylation

• Kathleen Dennis

• Tao Fan

• Theresa Geiman

• Qingsheng Yan

• Kathrin Muegge

抄録

Methylation patterns of the mammalian genome are thought to be crucial for development. The precise mechanisms designating specific genomic loci for methylation are not known. Targeted deletion of Lsh results in perinatal lethality with a rather normal development. We report here, however, that Lsh −/− mice show substantial loss of methylation throughout the genome. The hypomethylated loci comprise repetitive elements and single copy genes. This suggests that global genomic methylation is not absolutely required for normal embryogenesis. Based on the similarity of Lsh to other SNF2 chromatin remodeling proteins, it suggests that alteration of chromatin affects global methylation patterns in mice.

収録刊行物

• Genes & Development

  Genes & Development 15 (22), 2940-2944, 2001-11-15

  Cold Spring Harbor Laboratory

キーワード

• Developmental Biology
• Genetics

詳細情報

• CRID: 1363107369676268672
• NII論文ID: 30018917449
• DOI: 10.1101/gad.929101
• ISSN: 15495477
• ISSN: 08909369
• Web Site: https://syndication.highwire.org/content/doi/10.1101/gad.929101
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