ICE1: a regulator of cold-induced transcriptome and freezing tolerance in<i>Arabidopsis</i>

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<jats:p>Cold temperatures trigger the expression of the CBF family of transcription factors, which in turn activate many downstream genes that confer chilling and freezing tolerance to plants. We report here the identification of<jats:italic>ICE1</jats:italic>(<jats:underline><jats:italic>i</jats:italic></jats:underline><jats:italic>nducer of</jats:italic><jats:underline><jats:italic>C</jats:italic></jats:underline><jats:italic>BF</jats:italic><jats:underline><jats:italic>e</jats:italic></jats:underline><jats:italic>xpression</jats:italic><jats:underline><jats:italic>1</jats:italic></jats:underline>), an upstream transcription factor that regulates the transcription of<jats:italic>CBF</jats:italic>genes in the cold. An<jats:italic>Arabidopsis ice1</jats:italic>mutant was isolated in a screen for mutations that impair cold-induced transcription of a<jats:italic>CBF3</jats:italic>promoter-luciferase reporter gene. The<jats:italic>ice1</jats:italic>mutation blocks the expression of<jats:italic>CBF3</jats:italic>and decreases the expression of many genes downstream of<jats:italic>CBFs</jats:italic>, which leads to a significant reduction in plant chilling and freezing tolerance.<jats:italic>ICE1</jats:italic>encodes a MYC-like bHLH transcriptional activator. ICE1 binds specifically to the MYC recognition sequences in the<jats:italic>CBF3</jats:italic>promoter.<jats:italic>ICE1</jats:italic>is expressed constitutively, and its overexpression in wild-type plants enhances the expression of the<jats:italic>CBF</jats:italic>regulon in the cold and improves freezing tolerance of the transgenic plants.</jats:p>

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  • Genes & Development

    Genes & Development 17 (8), 1043-1054, 2003-04-02

    Cold Spring Harbor Laboratory

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