Association Studies of Variants in the Genes Involved in Pancreatic β-Cell Function in Type 2 Diabetes in Japanese Subjects

• Norihide Yokoi

  Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan

• Masao Kanamori

  Division of Health and Preventive Medicine, Department of Lifelong Sport, Biwako Seikei Sport College, Shiga, Japan

• Yukio Horikawa

  Department of Endocrinology, Diabetes and Rheumatology, Division of Bioregulatory Medicine, Gifu University School of Medicine, Gifu, Japan

• Jun Takeda

  Department of Endocrinology, Diabetes and Rheumatology, Division of Bioregulatory Medicine, Gifu University School of Medicine, Gifu, Japan

• Tokio Sanke

  Department of Clinical Laboratory Medicine, Wakayama University of Medical Science, Wakayama, Japan

• Hiroto Furuta

  First Department of Medicine, Wakayama University of Medical Science, Wakayama, Japan

• Kishio Nanjo

  First Department of Medicine, Wakayama University of Medical Science, Wakayama, Japan

• Hiroyuki Mori

  Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan

• Masato Kasuga

  Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan

• Kazuo Hara

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

• Takashi Kadowaki

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

• Yukio Tanizawa

  Division of Molecular Analysis of Human Disorders, Department of Bio-Signal Analysis, Yamaguchi University Graduate School of Medicine, Ube, Japan

• Yoshitomo Oka

  Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan

• Yukiko Iwami

  Division of Cell Replacement and Regenerative Medicine, Medical Research Institute, School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan

• Hisako Ohgawara

  Division of Cell Replacement and Regenerative Medicine, Medical Research Institute, School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan

• Yuichiro Yamada

  Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan

• Yutaka Seino

  Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan

• Hideki Yano

  Department of Internal Medicine, Hikone Municipal Hospital, Shiga, Japan

• Nancy J. Cox

  Departments of Medicine and Human Genetics, University of Chicago, Chicago, Illinois

• Susumu Seino

  Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan

抄録

Because impaired insulin secretion is characteristic of type 2 diabetes in Asians, including Japanese, the genes involved in pancreatic β-cell function are candidate susceptibility genes for type 2 diabetes. We examined the association of variants in genes encoding several transcription factors (TCF1, TCF2, HNF4A, ISL1, IPF1, NEUROG3, PAX6, NKX2–2, NKX6–1, and NEUROD1) and genes encoding the ATP-sensitive K+ channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) with type 2 diabetes in a Japanese cohort of 2,834 subjects. The exon 16 −3c/t variant rs1799854 in ABCC8 showed a significant association (P = 0.0073), and variants in several genes showed nominally significant associations (P < 0.05) with type 2 diabetes. Although the E23K variant rs5219 in KCNJ11 showed no association with diabetes in Japanese (for the K allele, odds ratio [OR] 1.08 [95% CI 0.97–1.21], P = 0.15), 95% CI around the OR overlaps in meta-analysis of European populations, suggesting that our results are not inconsistent with the previous studies. This is the largest association study so far conducted on these genes in Japanese and provides valuable information for comparison with other ethnic groups.

収録刊行物

• Diabetes

  Diabetes 55 (8), 2379-2386, 2006-08-01

  American Diabetes Association

キーワード

• Endocrinology, Diabetes and Metabolism
• Internal Medicine

詳細情報

• CRID: 1360292620100648704
• NII論文ID: 30020277660
• DOI: 10.2337/db05-1203
• ISSN: 1939327X
• ISSN: 00121797
• Web Site: https://journals.org/diabetes/diabetes/article-pdf/55/8/2379/384641/zdb00806002379.pdf
• Web Site: https://diabetesjournals.org/diabetes/article-pdf/55/8/2379/384641/zdb00806002379.pdf
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