Neoteny in Lymphocytes: <i>Rag1</i> and <i>Rag2</i> Expression in Germinal Center B Cells

DOI Web Site 被引用文献5件
  • Shuhua Han
    S. Han, B. Zheng, G. Kelsoe, Department of Microbiology and Immunology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA.
  • Biao Zheng
    S. Han, B. Zheng, G. Kelsoe, Department of Microbiology and Immunology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA.
  • David G. Schatz
    D. G. Schatz, Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Eugenia Spanopoulou
    E. Spanopoulou, Mount Sinai Cancer Center, New York, NY 10021, USA.
  • Garnett Kelsoe
    S. Han, B. Zheng, G. Kelsoe, Department of Microbiology and Immunology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA.

抄録

<jats:p> The products of the <jats:italic>Rag1</jats:italic> and <jats:italic>Rag2</jats:italic> genes drive genomic V(D)J rearrangements that assemble functional immunoglobulin and T cell antigen receptor genes. Expression of the <jats:italic>Rag</jats:italic> genes has been thought to be limited to developmentally immature lymphocyte populations that in normal adult animals are primarily restricted to the bone marrow and thymus. Abundant RAG1 and RAG2 protein and messenger RNA was detected in the activated B cells that populate murine splenic and Peyer's patch germinal centers. Germinal center B cells thus share fundamental characteristics of immature lymphocytes, raising the possibility that antigen-dependent secondary V(D)J rearrangements modify the peripheral antibody repertoire. </jats:p>

収録刊行物

  • Science

    Science 274 (5295), 2094-2097, 1996-12-20

    American Association for the Advancement of Science (AAAS)

被引用文献 (5)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ