Experimental Evolution of Parasites

• Dieter Ebert

  The author is at the Universität Basel, Zoologisches Institut, Rheinsprung 9, 4051 Basel, Switzerland.

抄録

Serial passage experiments are a form of experimental evolution that is frequently used in applied sciences; for example, in vaccine development. During these experiments, molecular and phenotypic evolution can be monitored in real time, providing insights into the causes and consequences of parasite evolution. Within-host competition generally drives an increase in a parasite's virulence in a new host, whereas the parasite becomes avirulent to its former host, indicating a trade-off between parasite fitnesses on different hosts. Understanding why parasite virulence seldom escalates similarly in natural populations could help us to manage virulence and deal with emerging diseases.

収録刊行物

• Science

  Science 282 (5393), 1432-1436, 1998-11-20

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1360292621062173952
• NII論文ID: 30020359756
• DOI: 10.1126/science.282.5393.1432
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.282.5393.1432
• データソース種別:
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  • CiNii Articles