The Product of the Proto-Oncogene c- <i>cbl</i> : A Negative Regulator of the Syk Tyrosine Kinase

DOI Web Site 被引用文献2件
  • Yasuo Ota
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892–5430, USA.
  • Lawrence E. Samelson
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892–5430, USA.

抄録

<jats:p>Engagement of antigen and immunoglobulin receptors on hematopoietic cells is directly coupled to activation of nonreceptor protein tyrosine kinases (PTKs) that then phosphorylate critical intracellular substrates. In mast cells stimulated through the FcɛRI receptor, activation of several PTKs including Syk leads to degranulation and release of such mediators of the allergic response as histamine and serotonin. Regulation of Syk function occurred through interaction with the Cbl protein, itself a PTK substrate in this system. Overexpression of Cbl led to inhibition of Syk and suppression of serotonin release from mast cells, demonstrating its ability to inhibit a nonreceptor tyrosine kinase. Complex adaptor proteins such as Cbl can directly regulate the functions of the proteins they bind.</jats:p>

収録刊行物

  • Science

    Science 276 (5311), 418-420, 1997-04-18

    American Association for the Advancement of Science (AAAS)

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