Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus
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- Patrick Blanco
- Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
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- A. Karolina Palucka
- Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
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- Michelle Gill
- Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
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- Virginia Pascual
- Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
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- Jacques Banchereau
- Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
Abstract
<jats:p>Dendritic cells (DCs) are important in regulating both immunity and tolerance. Hence, we hypothesized that systemic lupus erythematosus (SLE), an autoimmune disease characterized by autoreactive B and T cells, may be caused by alterations in the functions of DCs. Consistent with this, monocytes from SLE patients' blood were found to function as antigen-presenting cells, in vitro. Furthermore, serum from SLE patients induced normal monocytes to differentiate into DCs. These DCs could capture antigens from dying cells and present them to CD4-positive T cells. The capacity of SLE patients' serum to induce DC differentiation correlated with disease activity and depended on the actions of interferon-α (IFN-α). Thus, unabated induction of DCs by IFN-α may drive the autoimmune response in SLE.</jats:p>
Journal
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- Science
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Science 294 (5546), 1540-1543, 2001-11-16
American Association for the Advancement of Science (AAAS)
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Keywords
Details 詳細情報について
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- CRID
- 1363107371367755648
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- NII Article ID
- 30020370254
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- ISSN
- 10959203
- 00368075
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- Data Source
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- Crossref
- CiNii Articles