SynCAM, a Synaptic Adhesion Molecule That Drives Synapse Assembly

• Thomas Biederer

  Center for Basic Neuroscience, Departments of

• Yildirim Sara

  Center for Basic Neuroscience, Departments of

• Marina Mozhayeva

  Center for Basic Neuroscience, Departments of

• Deniz Atasoy

  Center for Basic Neuroscience, Departments of

• Xinran Liu

  Center for Basic Neuroscience, Departments of

• Ege T. Kavalali

  Center for Basic Neuroscience, Departments of

• Thomas C. Südhof

  Center for Basic Neuroscience, Departments of

抄録

Synapses, the junctions between nerve cells through which they communicate, are formed by the coordinated assembly and tight attachment of pre- and postsynaptic specializations. We now show that SynCAM is a brain-specific, immunoglobulin domain–containing protein that binds to intracellular PDZ-domain proteins and functions as a homophilic cell adhesion molecule at the synapse. Expression of the isolated cytoplasmic tail of SynCAM in neurons inhibited synapse assembly. Conversely, expression of full-length SynCAM in nonneuronal cells induced synapse formation by cocultured hippocampal neurons with normal release properties. Glutamatergic synaptic transmission was reconstituted in these nonneuronal cells by coexpressing glutamate receptors with SynCAM, which suggests that a single type of adhesion molecule and glutamate receptor are sufficient for a functional postsynaptic response.

収録刊行物

• Science

  Science 297 (5586), 1525-1531, 2002-08-30

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1362262944857902336
• NII論文ID: 30020380917
• DOI: 10.1126/science.1072356
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.1072356
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