Noncoding RNAs of Trithorax Response Elements Recruit <i>Drosophila</i> Ash1 to Ultrabithorax
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- Tilman Sanchez-Elsner
- Department of Biochemistry, University of California, Riverside, CA 92521, USA.
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- Dawei Gou
- Department of Biochemistry, University of California, Riverside, CA 92521, USA.
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- Elisabeth Kremmer
- Department of Biochemistry, University of California, Riverside, CA 92521, USA.
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- Frank Sauer
- Department of Biochemistry, University of California, Riverside, CA 92521, USA.
抄録
<jats:p> Homeotic genes contain cis-regulatory trithorax response elements (TREs) that are targeted by epigenetic activators and transcribed in a tissue-specific manner. We show that the transcripts of three TREs located in the <jats:italic>Drosophila</jats:italic> homeotic gene <jats:italic>Ultrabithorax</jats:italic> ( <jats:italic>Ubx</jats:italic> ) mediate transcription activation by recruiting the epigenetic regulator Ash1 to the template TREs. TRE transcription coincides with <jats:italic>Ubx</jats:italic> transcription and recruitment of Ash1 to TREs in <jats:italic>Drosophila</jats:italic> . The SET domain of Ash1 binds all three TRE transcripts, with each TRE transcript hybridizing with and recruiting Ash1 only to the corresponding TRE in chromatin. Transgenic transcription of TRE transcripts restores recruitment of Ash1 to <jats:italic>Ubx</jats:italic> TREs and restores <jats:italic>Ubx</jats:italic> expression in <jats:italic>Drosophila</jats:italic> cells and tissues that lack endogenous TRE transcripts. Small interfering RNA–induced degradation of TRE transcripts attenuates Ash1 recruitment to TREs and <jats:italic>Ubx</jats:italic> expression, which suggests that noncoding TRE transcripts play an important role in epigenetic activation of gene expression. </jats:p>
収録刊行物
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- Science
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Science 311 (5764), 1118-1123, 2006-02-24
American Association for the Advancement of Science (AAAS)
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詳細情報 詳細情報について
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- CRID
- 1360011146318707072
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- NII論文ID
- 30020394233
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- ISSN
- 10959203
- 00368075
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- データソース種別
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