Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase

Robert Zimmermann, Juliane G. Strauss, Guenter Haemmerle, Gabriele Schoiswohl, Ruth Birner-Gruenberger, Monika Riederer, Achim Lass, Georg Neuberger, Frank Eisenhaber, Albin Hermetter, Rudolf Zechner

doi:10.1126/science.1100747

Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase

DOI Web Site 被引用文献64件

Robert Zimmermann

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Juliane G. Strauss

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Guenter Haemmerle

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Gabriele Schoiswohl

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Ruth Birner-Gruenberger

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Monika Riederer

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Achim Lass

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Georg Neuberger

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Frank Eisenhaber

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Albin Hermetter

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Rudolf Zechner

Institute of Molecular Biosciences, University of Graz, Graz, Austria.

抄録

<jats:p>Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of obesity and insulin resistance. Until now, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. Here, we report that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. It is interesting that ATGL contains a “patatin domain” common to plant acyl-hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.</jats:p>