Sorbitol Pathway: Presence in Nerve and Cord with Substrate Accumulation in Diabetes

• Kenneth H. Gabbay

  Department of Medicine (Diabetes Unit), Massachusetts General Hospital, and Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston

• Lorenzo O. Merola

  Department of Medicine (Diabetes Unit), Massachusetts General Hospital, and Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston

• Richard A. Field

  Department of Medicine (Diabetes Unit), Massachusetts General Hospital, and Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston

抄録

Glucose, sorbitol, fructose, and inositol are present in peripheral nerve and spinal cord. Marked elevation of these substances occurs in these tissues in mildly diabetic animals. These alterations provide biochemical mechanisms which could be significant in the etiology of diabetic neuropathy.

収録刊行物

• Science

  Science 151 (3707), 209-210, 1966-01-14

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1360292621212917248
• NII論文ID: 30020486304
• DOI: 10.1126/science.151.3707.209
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.151.3707.209
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