Myxovirus-Like Structures in a Case of Human Chronic Polymyositis

  • Shi-ming Chou
    Department of Pathology and Regional Primate Research Center, University of Wisconsin Medical School, Madison

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<jats:p>Intranuclear and intracytoplasmic aggregates of filaments with tubular structures and transverse striations occurred in muscle tissues biopsied from a patient with chronic polymyositis. The filamentous tubules bear a close resemblance to the incomplete form of myxovirus in which the envelope is missing. Three biopsies from the same patient, taken during a period of 1½ years, all revealed these structures. This finding provides presumptive evidence that a chronic persistent viral infection may be involved in the pathogenesis of chronic polymyositis.</jats:p>

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  • Science

    Science 158 (3807), 1453-1455, 1967-12-15

    American Association for the Advancement of Science (AAAS)

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