Bombesin: Potent Effects on Thermoregulation in the Rat

DOI Web Site 被引用文献3件
  • Marvin Brown
    Laboratories for Neuroendocrinology, Salk Institute, San Diego, California 92112
  • Jean Rivier
    Laboratories for Neuroendocrinology, Salk Institute, San Diego, California 92112
  • Wylie Vale
    Laboratories for Neuroendocrinology, Salk Institute, San Diego, California 92112

抄録

<jats:p> Several vasoactive peptides administered intracisternally have been assessed for the effect of lowering the core temperature of rats exposed to cold. Peptides structurally related to neurotensin lower core temperature while those related to substance P do not. The tetradecapeptide bombesin, originally isolated from the extracts of the skin of the frog <jats:italic>Bombina bombina</jats:italic> , is 10 <jats:sup>4</jats:sup> times more potent than neurotensin in lowering core temperature, with a minimal effective dose less than or equal to 1 nanogram per 200 grams of body weight. Thus bombesin is one of the most potent peptides reported to affect the central nervous system. </jats:p>

収録刊行物

  • Science

    Science 196 (4293), 998-1000, 1977-05-27

    American Association for the Advancement of Science (AAAS)

被引用文献 (3)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ