Infidelity of DNA Synthesis in Vitro: Screening for Potential Metal Mutagens or Carcinogens

DOI Web Site 被引用文献5件
  • Michael A. Sirover
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
  • Lawrence A. Loeb
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111

抄録

<jats:p>Thirty-one metal salts have been tested for their ability to affect the accuracy of DNA synthesis in vitro. All ten salts of metal carcinogens decreased the fidelity of DNA synthesis. Of the three metals which beforehand were considered to be possible mutagens or carcinogens, only one decreased fidelity. In contrast, 17 noncarcinogenic metal salts did not affect fidelity even when present at concentrations that were clearly inhibitory.</jats:p>

収録刊行物

  • Science

    Science 194 (4272), 1434-1436, 1976-12-24

    American Association for the Advancement of Science (AAAS)

被引用文献 (5)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ