Oxytocin Receptors: Triggers for Parturition and Lactation?

• Melvyn S. Soloff

  Department of Biochemistry, Medical College of Ohio, Toledo 43699

• Maria Alexandrova

  Department of Biochemistry, Medical College of Ohio, Toledo 43699

• Martha J. Fernstrom

  Department of Biochemistry, Medical College of Ohio, Toledo 43699

抄録

Specific binding of tritiated oxytocin to uterine receptors of pregnant rats increases dramatically at term and is maximal during labor. In mammary glands the increase in binding is gradual, reaching a maximum during the lactation period. Concomitant changes in the sensitivity of the uterus and mammary gland to oxytocin indicate that the receptor concentration is of functional significance. Oxytocin receptors, therefore, may regulate the response of the target organs to circulating oxytocin and thereby control the onset of labor and lactation. Ovarian steroids participate in the regulation of oxytocin receptors in a manner as yet unclarified.

収録刊行物

• Science

  Science 204 (4399), 1313-1315, 1979-06-22

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363107370889511936
• NII論文ID: 30020515060
• DOI: 10.1126/science.221972
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.221972
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