A Sign Inversion Mechanism for Enzymatic Supercoiling of DNA

• Patrick O. Brown

• Nicholas R. Cozzarelli

抄録

Both the introduction and the removal of supertwists by DNA gyrase change the linking number of DNA in steps of two. This surprising finding provides strong evidence that gyrase acts by a mechanism, called sign inversion, whereby a positive supercoil is directly inverted into a negative one via a transient double-strand break.

収録刊行物

• Science

  Science 206 (4422), 1081-1083, 1979-11-30

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1362825895014124288
• NII論文ID: 30020516807
• DOI: 10.1126/science.227059
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.227059
• データソース種別:
  • Crossref
  • CiNii Articles