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- Ray Sanchez-Pescador
- Chiron Research Laboratories, Chiron Corporation, Emeryville, California 94608,
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- Michael D. Power
- Chiron Research Laboratories, Chiron Corporation, Emeryville, California 94608,
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- Philip J. Barr
- Chiron Research Laboratories, Chiron Corporation, Emeryville, California 94608,
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- Kathelyn S. Steimer
- Chiron Research Laboratories, Chiron Corporation, Emeryville, California 94608,
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- Michelle M. Stempien
- Chiron Research Laboratories, Chiron Corporation, Emeryville, California 94608,
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- Sheryl L. Brown-Shimer
- Chiron Research Laboratories, Chiron Corporation, Emeryville, California 94608,
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- Wendy W. Gee
- Chiron Research Laboratories, Chiron Corporation, Emeryville, California 94608,
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- Andre Renard
- Chiron Research Laboratories, Chiron Corporation, Emeryville, California 94608,
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- Anne Randolph
- Chiron Research Laboratories, Chiron Corporation, Emeryville, California 94608,
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- Jay A. Levy
- Cancer Research Institute, University of California, School of Medicine, San Francisco, California 94143.
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- Dino Dina
- Chiron Research Laboratories, Chiron Corporation, Emeryville, California 94608,
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- Paul A. Luciw
- Chiron Research Laboratories, Chiron Corporation, Emeryville, California 94608,
抄録
<jats:p> The nucleotide sequence of molecular clones of DNA from a retrovirus, ARV-2, associated with the acquired immune deficiency syndrome (AIDS) was determined. Proviral DNA of ARV-2 (9737 base pairs) has long terminal repeat structures (636 base pairs) and long open reading frames encoding <jats:italic>gag</jats:italic> (506 codons), <jats:italic>pol</jats:italic> (1003 codons), and <jats:italic>env</jats:italic> (863 codons) genes. Two additional open reading frames were identified. Significant amino acid homology with several other retroviruses was noted in the predicted product of <jats:italic>gag</jats:italic> and <jats:italic>pol</jats:italic> , but ARV-2 was as closely related to murine and avian retroviruses as it was to human T-cell leukemia viruses (HTLV-I and HTLV-II). By means of an SV-40 vector in transfected simian cells, the cloned <jats:italic>gag</jats:italic> and <jats:italic>env</jats:italic> genes of ARV-2 were shown to express viral proteins. </jats:p>
収録刊行物
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- Science
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Science 227 (4686), 484-492, 1985-02
American Association for the Advancement of Science (AAAS)
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詳細情報
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- CRID
- 1360574095161399936
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- NII論文ID
- 30020525697
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- ISSN
- 10959203
- 00368075
- http://id.crossref.org/issn/00368075
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- データソース種別
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- Crossref
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