Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

• Yuji Yamanashi

  Department of Oncology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108, Japan.

• Terutaka Kakiuchi

  Department of Allergology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108, Japan.

• Junichiro Mizuguchi

  Department of Applied Immunology, National Institute of Health, Shinagawa-ku, Tokyo 141, Japan.

• Tadashi Yamamoto

  Department of Oncology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108, Japan.

• Kumao Toyoshima

  Department of Oncology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108, Japan.

抄録

Antigen is thought to cross-link membrane-bound immunoglobulins (Igs) of B cells, causing proliferation and differentiation or the inhibition of growth. Protein tyrosine kinases are probably involved in signal transduction for cell proliferation and differentiation. The Src-like protein tyrosine kinase Lyn is expressed preferentially in B cells. The Lyn protein and its kinase activity could be coimmunoprecipitated with IgM from detergent lysates. Cross-linking of membrane-bound IgM induced a rapid increase in tyrosine phosphorylation of at least ten distinct proteins of B cells. Thus, Lyn is physically associated with membrane-bound IgM, and is suggested to participate in antigen-mediated signal transduction.

収録刊行物

• Science

  Science 251 (4990), 192-194, 1991-01-11

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1361981469966608128
• NII論文ID: 30020538054
• DOI: 10.1126/science.1702903
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.1702903
• データソース種別:
  • Crossref
  • CiNii Articles