Linkage Analysis of <i>IL4</i> and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

DOI Web Site 被引用文献37件
  • David G. Marsh
    Johns Hopkins Asthma and Allergy Center, School of Medicine, Baltimore, MD 21224, USA.
  • John D. Neely
    Johns Hopkins Asthma and Allergy Center, School of Medicine, Baltimore, MD 21224, USA.
  • Daniel R. Breazeale
    Department of Epidemiology, Johns Hopkins School of Hygiene, Baltimore, MD 21205, USA.
  • Balaram Ghosh
    Johns Hopkins Asthma and Allergy Center, School of Medicine, Baltimore, MD 21224, USA.
  • Linda R. Freidhoff
    Johns Hopkins Asthma and Allergy Center, School of Medicine, Baltimore, MD 21224, USA.
  • Eva Ehrlich-Kautzky
    Johns Hopkins Asthma and Allergy Center, School of Medicine, Baltimore, MD 21224, USA.
  • Carsten Schou
    Allergologisk (ALK) Laboratorium A/S, Bøge Allée 10-12, DK-2970, Hørsholm, Denmark.
  • Guha Krishnaswamy
    Johns Hopkins Asthma and Allergy Center, School of Medicine, Baltimore, MD 21224, USA.
  • Terri H. Beaty
    Department of Epidemiology, Johns Hopkins School of Hygiene, Baltimore, MD 21205, USA.

抄録

<jats:p> Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration. No linkage was found between these markers and specific IgE antibody concentrations. Analysis of total IgE within a subset of 128 IgE antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially to the interleukin-4 gene ( <jats:italic>IL4</jats:italic> ). A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that <jats:italic>IL4</jats:italic> or a nearby gene in 5q31.1 regulates IgE production in a nonantigen-specific (noncognate) fashion. </jats:p>

収録刊行物

  • Science

    Science 264 (5162), 1152-1156, 1994-05-20

    American Association for the Advancement of Science (AAAS)

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