Cardiac Malformation in Neonatal Mice Lacking Connexin43

DOI Web Site 被引用文献23件
  • Andrew G. Reaume
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  • Paul A. de Sousa
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  • Sarang Kulkarni
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  • B. Lowell Langille
    Max Bell Research Centre, Toronto General Division, Toronto, Ontario M5G 2C4, Canada, and Department of Pathology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Daguang Zhu
    Molecular Genetics Unit and Department of Zoology, University of Western Ontario, London, Ontario N6A 5B7, Canada.
  • Tyler C. Davies
    Molecular Genetics Unit and Department of Zoology, University of Western Ontario, London, Ontario N6A 5B7, Canada.
  • Subhash C. Juneja
    Molecular Genetics Unit and Department of Zoology, University of Western Ontario, London, Ontario N6A 5B7, Canada.
  • Gerald M. Kidder
    Molecular Genetics Unit and Department of Zoology, University of Western Ontario, London, Ontario N6A 5B7, Canada.
  • Janet Rossant
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

抄録

<jats:p>Gap junctions are made up of connexin proteins, which comprise a multigene family in mammals. Targeted mutagenesis of connexin43 (Cx43), one of the most prevalent connexin proteins, showed that its absence was compatible with survival of mouse embryos to term, even though mutant cell lines showed reduced dye coupling in vitro. However, mutant embryos died at birth, as a result of a failure in pulmonary gas exchange caused by a swelling and blockage of the right ventricular outflow tract from the heart. This finding suggests that Cx43 plays an essential role in heart development but that there is functional compensation among connexins in other parts of the developing fetus.</jats:p>

収録刊行物

  • Science

    Science 267 (5205), 1831-1834, 1995-03-24

    American Association for the Advancement of Science (AAAS)

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