<i>KAI1</i> , a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p11.2

• Jin-Tang Dong

• Pattie W. Lamb

• Carrie W. Rinker-Schaeffer

• Jasminka Vukanovic

• Tomohiko Ichikawa

• John T. Isaacs

• J. Carl Barrett

Abstract

A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, designated KAI1 , was reduced in human cell lines derived from metastatic prostate tumors. KAI1 specifies a protein of 267 amino acids, with four hydrophobic and presumably transmembrane domains and one large extracellular hydrophilic domain with three potential N-glycosylation sites. KAI1 is evolutionarily conserved, is expressed in many human tissues, and encodes a member of a structurally distinct family of leukocyte surface glycoproteins. Decreased expression of this gene may be involved in the malignant progression of prostate and other cancers.

Journal

• Science

  Science 268 (5212), 884-886, 1995-05-12

  American Association for the Advancement of Science (AAAS)

Keywords

• Multidisciplinary

Details

• CRID: 1364233268189947776
• NII Article ID: 30020562598
• DOI: 10.1126/science.7754374
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.7754374
• Data Source:
  • Crossref
  • CiNii Articles