Diabetes Complications: Why Is Glucose Potentially Toxic?

DOI Web Site 被引用文献4件
  • Daniel Porte
    The authors are in the Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Department of Veteran Affairs Puget Sound Health Care System and University of Washington, Seattle, WA 98108, USA.
  • Michael W. Schwartz
    The authors are in the Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Department of Veteran Affairs Puget Sound Health Care System and University of Washington, Seattle, WA 98108, USA.

抄録

<jats:p> Individuals with diabetes can lead quite normal lives when their blood sugar is controlled by insulin injections. But these injections cannot maintain blood glucose at concentrations as low and stable as they are in normal individuals. The resulting highe r glucose concentrations eventually lead to the complications of diabetes—damage to blood vessels, heart disease, blindness, stroke, and kidney failure. In a report in this week's issue (Ishii <jats:italic>et al.</jats:italic> , p. 728), a new inhibitor of protein kinase C is shown to inhibit some indices of glucose toxicity in an animal model of diabetes. In their Perspective, Porte and Schwartz discuss how close we are to being able to treat these complication s in patients. </jats:p>

収録刊行物

  • Science

    Science 272 (5262), 699-699, 1996-05-03

    American Association for the Advancement of Science (AAAS)

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