Human Metapneumovirus Induces a Profile of Lung Cytokines Distinct from That of Respiratory Syncytial Virus
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- Antonieta Guerrero-Plata
- Departments of Pediatrics
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- Antonella Casola
- Departments of Pediatrics
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- Roberto P. Garofalo
- Departments of Pediatrics
抄録
<jats:title>ABSTRACT</jats:title> <jats:p>Lung cytokine and chemokine production by BALB/c mice infected with human metapneumovirus (hMPV) was compared to respiratory syncytial virus (RSV)-infected mice. hMPV infection induced lower levels of the inflammatory cytokines interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha but was a more potent inducer of granulocyte-macrophage colony-stimulating factor and triggered a more sustained production of the CXC chemokine KC compared to RSV. hMPV was a stronger inducer of both alpha interferon (IFN-α) and IFN-γ responses than RSV. In regard to immunomodulatory cytokines, hMPV failed to induce detectable IL-10 or IL-12p70 but was a potent inducer of IL-12 p40 subunit. The implications for hMPV pathogenesis are discussed.</jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 79 (23), 14992-14997, 2005-12-15
American Society for Microbiology
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詳細情報 詳細情報について
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- CRID
- 1361981468677412480
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- NII論文ID
- 30020800922
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- ISSN
- 10985514
- 0022538X
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- データソース種別
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- Crossref
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