<i>Vibrio cholerae tolC</i> Is Required for Bile Resistance and Colonization

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  • James E. Bina
    <!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115
  • John J. Mekalanos
    <!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115
  • J. T. Barbieri
    editor

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<jats:title>ABSTRACT</jats:title> <jats:p> TolC and its homologues are outer membrane proteins that are essential for the transport of many molecules across the cell envelope. In this study we characterized the gene encoding <jats:italic>Vibrio cholerae</jats:italic> TolC. <jats:italic>V. cholerae tolC</jats:italic> mutants failed to secrete the RTX cytotoxin, were hypersensitive to antimicrobial agents, and were deficient in intestinal colonization. </jats:p>

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