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- Nicole P. Juffermans
- Laboratory of Experimental Internal Medicine
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- Jaklien C. Leemans
- Laboratory of Experimental Internal Medicine
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- Sandrine Florquin
- Department of Pathology
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- Annelies Verbon
- Laboratory of Experimental Internal Medicine
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- Arend H. Kolk
- Academic Medical Center, University of Amsterdam, and the Royal Tropical Institute, Amsterdam, The Netherlands
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- Peter Speelman
- Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine, and AIDS
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- Sander J. H. van Deventer
- Laboratory of Experimental Internal Medicine
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- Tom van der Poll
- Laboratory of Experimental Internal Medicine
抄録
<jats:title>ABSTRACT</jats:title><jats:p>Oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs activate immune cells to produce cytokines. CpG ODNs protect mice against infections with intracellular bacteria by the induction of a T helper 1 (Th1) response. To determine the effect of CpG ODNs in pulmonary tuberculosis, mice were treated with CpG ODNs or control ODNs at the time of intranasal infection. CpG ODNs reduced mycobacterial outgrowth for up to 5 weeks after<jats:italic>Mycobacterium tuberculosis</jats:italic>infection and were associated with a decrease in inflammation in lung tissue. CpG treatment was also associated with elevated levels of gamma interferon (IFN-γ) and decreased levels of interleukin 4 in the lungs and an increased capacity of splenocytes to secrete Th1-type cytokines. CpG ODNs given 2 weeks after infection were still able to reduce mycobacterial outgrowth and to enhance a Th1 response 5 weeks postinfection. Administration of CpG ODNs to IFN-γ-gene-deficient mice failed to reduce mycobacterial outgrowth. These data suggest that CpG ODNs improve host defense during pulmonary tuberculosis by an IFN-γ-dependent mechanism.</jats:p>
収録刊行物
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- Infection and Immunity
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Infection and Immunity 70 (1), 147-152, 2002-01
American Society for Microbiology
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詳細情報 詳細情報について
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- CRID
- 1362262945987757952
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- NII論文ID
- 30020829695
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- ISSN
- 10985522
- 00199567
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- データソース種別
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